Leo Heunks Selected Research

Monoclonal Antibodies

12/2020

Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial.

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Leo Heunks Research Topics

Disease

10	Critical Illness (Critically Ill) 01/2023 - 10/2018
8	Respiratory Insufficiency (Respiratory Failure) 03/2023 - 03/2016
7	COVID-19 01/2024 - 12/2020
4	Atrophy 01/2023 - 12/2017
4	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2022 - 01/2019
3	Patient-Ventilator Asynchrony 12/2020 - 10/2017
2	Pulmonary Edema 01/2023 - 02/2022
2	Inflammation (Inflammations) 01/2023 - 12/2020
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 07/2011
2	Heart Failure 11/2019 - 11/2016
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/2023
1	Neuroinflammatory Diseases 01/2023
1	Necrosis 01/2023
1	Pneumonia (Pneumonitis) 12/2020
1	Dyspnea (Shortness of Breath) 12/2020
1	Cough 01/2020
1	Body Weight (Weight, Body) 01/2019
1	Respiratory Acidosis 01/2019
1	Muscular Atrophy (Muscle Atrophy) 12/2017
1	Low Cardiac Output 11/2016
1	Emphysema 07/2011

Drug/Important Bio-Agent (IBA)

2	Biomarkers (Surrogate Marker)IBA 11/2023 - 01/2023
2	Imatinib Mesylate (Gleevec)FDA Link 01/2023 - 02/2022
2	ChemokinesIBA 01/2023 - 01/2021
2	CytokinesIBA 01/2023 - 01/2021
2	Neuromuscular Blocking AgentsIBA 07/2022 - 12/2020
2	Complement System Proteins (Complement)IBA 01/2021 - 12/2020
2	Simendan (Levosimendan)IBA 11/2019 - 11/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2017 - 07/2011
1	procollagen Type III-N-terminal peptide (PIIP)IBA 11/2023
1	ThrombomodulinIBA 01/2023
1	Triggering Receptor Expressed on Myeloid Cells-1IBA 01/2023
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021
1	LigandsIBA 01/2021
1	AnaphylatoxinsIBA 12/2020
1	Oxygen (Dioxygen)IBA 12/2020
1	vilobelimabIBA 12/2020
1	Monoclonal AntibodiesIBA 12/2020
1	Brain Natriuretic Peptide (Natrecor)FDA Link 11/2019
1	UlaritideIBA 11/2019
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 12/2017
1	Peptide Hydrolases (Proteases)FDA Link 12/2017
1	EnzymesIBA 12/2017
1	CalpainIBA 12/2017
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 12/2017
1	UbiquitinIBA 12/2017
1	calpeptinIBA 12/2017
1	calpain inhibitorsIBA 12/2017
1	Pancreatic Elastase (Elastase)IBA 07/2011
1	Bortezomib (Velcade)FDA Link 07/2011
1	Contractile ProteinsIBA 07/2011

Therapy/Procedure

13	Artificial Respiration (Mechanical Ventilation) 03/2023 - 10/2018
6	Mechanical Ventilators (Ventilator) 10/2021 - 10/2017
4	Critical Care (Surgical Intensive Care) 03/2023 - 01/2020
2	Catheters 01/2023 - 02/2022
2	Cannula 10/2022 - 01/2022
2	Ventilator Weaning 10/2021 - 01/2020
1	Length of Stay 02/2022
1	Contraindications 01/2022
1	Therapeutics 11/2019
1	Tracheostomy 01/2019
1	Interactive Ventilatory Support 03/2016